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||| OMEGA-3
MAY PROMOTE YOUTHFUL BIOLOGICAL AGE |
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Posted on 2010-01-27 Cardio-Vascular | F
atty Acids, Lipids & Oils | Mechanisms
of Aging |
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Telomeres are the endcaps on chromosomes,
and the number of times that telomeres divide
during cellular replication has been linked
to cellular aging and death.
Ramin Farzaneh-Far, from the University
of California San Francisco (USA), and colleagues
studied a group of 608 patients with stable
coronary artery disease for a six-year period,
measuring leukocyte telomere length at the
study's start and at the five-year mark.
The team then modeled the association of
omega-3 fatty acids (docosahexaenoic acid
[DHA] and eicosapentaenoic acid [EPA]) with
subsequent change in telomere length.
The researchers found that those subjects
in the lowest quartile of DHA+EPA experienced
the fastest rate of telomere shortening,
whereas those in the highest quartile experienced
the slowest rate of telomere shortening.
Further, each unit increase in DHA/EPA levels
was associated with a 32% reduction in the
odds of telomere shortening Speculating
that omega-3s may protect against oxidative
stress, or increase the activity of the
telomerase enzyme, which may then decrease
telomere shortening by creating more accurate
telomere copies, the researchers conclude
that: "Among this cohort of patients
with coronary artery disease, there was
an inverse relationship between baseline
blood levels of marine omega-3 fatty acids
and the rate of telomere shortening over
5 years."
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